Interim results of two large randomized, placebo-controlled trials (RCTs) demonstrate ~95% relative efficacy in preventing COVID-19 (Pfizer, Moderna). The AstraZeneca/Oxford vaccine has ~70% relative efficacy. Absolute benefits will vary with baseline risk and time but if annual risk of developing COVID-19 is 20%, then vaccine would decrease risk to 1% (6% with AstraZeneca/Oxford). These vaccines...
Tag: mortality
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Prostate Cancer Screening: No Effect on Overall Mortality
Routine prostate-specific antigen (PSA)-based screening for prostate cancer remains controversial, as the debate continues over the bank between potential benefits and potential harm. A new systematic review and meta-analysis has found that at best, prostate cancer screening using a PSA blood test leads to a small reduction in disease-specific mortality over 10 years, but it...